The Natural Progression of Gambiense Sleeping Sickness: What Is the Evidence?
نویسندگان
چکیده
منابع مشابه
The Natural Progression of Gambiense Sleeping Sickness: What Is the Evidence?
Gambiense human African trypanosomiasis (HAT, sleeping sickness) is widely assumed to be 100% pathogenic and fatal. However, reports to the contrary exist, and human trypano-tolerance has been postulated. Furthermore, there is uncertainty about the actual duration of both stage 1 and stage 2 infection, particularly with respect to how long a patient remains infectious. Understanding such basic ...
متن کاملDo Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?
Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between 1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations at risk, drug donations, and efforts by national and international stakeholders have brought the epidemic under control with <2200 cases in 2016. The World Health Organization (WHO) has set the goals of gambiense-HAT elimination ...
متن کاملNECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness
Fatal if untreated, human African trypanosomiasis (HAT; sleeping sickness) afflicts an estimated 50,000–70,000 people each year [1], all in sub-Saharan Africa, with only a minority of cases (nearly 12,000 in 2008) being reported [2]. HAT is one of four neglected tropical diseases (NTDs) identified by the World Health Organization (WHO) as requiring Innovative and Intensified Disease Management ...
متن کاملGambiense sleeping sickness: re-emerging and soon untreatable?
Towards the end of the 1950s, sleeping sickness caused by Trypanosoma brucei gambiense was believed to be on the verge of eradication. Today, however, it has returned with a vengeance, mainly because of a deterioration of control activities, severe disruptions of health services, and population movements into high-risk areas. For example, over the last ten years, annual detection rates of the d...
متن کاملEstimates of the duration of the early and late stage of gambiense sleeping sickness
BACKGROUND The durations of untreated stage 1 (early stage, haemo-lymphatic) and stage 2 (late stage, meningo-encephalitic) human African trypanosomiasis (sleeping sickness) due to Trypanosoma brucei gambiense are poorly quantified, but key to predicting the impact of screening on transmission. Here, we outline a method to estimate these parameters. METHODS We first model the duration of stag...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2008
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0000303